This test will detect abnormalities in chromosome number and large deletions/duplications of chromosome material, as well as balanced chromosome rearrangements.
Please note: We recommend microarray analysis as the cytogenetic test for POC samples. For more information about the microarray, please click here.
The advantages of POC microarrays are:
- it utilizes uncultured DNA, which overcomes many of the limitations of G-banded analysis, including cell culture failure, suboptimal chromosome preparations and maternal overgrowth of cells
- it has the potential to detect chromosomal abnormalities that cannot be visualized by G-banded analysis
- it provides at least a ten-fold increase in the detection of chromosomal imbalances compared to G-banded analysis
- it has a shorter turnaround time since cells do not have to be cultured
Chromosome analysis performed on POC is warranted for the evaluation of any spontaneous pregnancy loss and can provide a diagnosis as well as the recurrence risks of chromosome problems in a future pregnancy.
Chromosome analysis on non-cancerous solid tissue.
Chromosome analysis by ISCN and ACMG guidelines; minimum band resolution of 450.
≥15-30 mg chorionic villi/placental tissue using sterile technique. Place in sterile tube(s) with transport media.
Tissues fixed in formalin cannot be used.
The laboratory cannot legally accept entire fetuses/stillbirths. Must be a part of an individual.
- Chromosomal Microarray, EmArray Cyto POC (CMPOC) – may detect microdeletions/duplications that are not visible by chromosome analysis and is recommended as a first tier diagnostic test.
- Infertility Panel: Female (MG)
- Infertility Panel: Male (MH)