Pharmacogenetics Pain Management and Psychotropic Panel

Pharmacogenomics (or pharmacogenetics), abbreviated PGx, is the study of how genes affect a person’s response to certain drugs. PGx testing uses genetic information to predict how individual patients will metabolize some prescription medications. This prediction allows an effective dose to be tailored to a person’s genetic makeup, helping to prevent adverse drug reactions. Pharmacogentics Extended Test targets variants to genotype for various haplotypes among the following 10 genes.

Genes and Alleles Tested:
ANKK1/DRD2 DRD2:Taq1A;
COMT NM_000754.3:c.472G>A(p.V158M); rs4680
CYP1A2 *1C, *1D, *1E, *1F, *1J, *1K, *1L, *1V, *1W;
CYP2B6 *7, *16, *5, *6, *9, *18, *22;
CYP2C19 *2, *3, *4, *4B, *5, *6, *7, *8, *9, *10, *17;
CYP2C9 *2, *3, *4, *5, *6, *11;
CYP2D6 *2, *3, *4, *4M, *6, *7, *8, *9, *10, *14A, *14B, *17, *29, *41, *5 (gene deletion), XN (gene duplication);
CYP3A4 *1B, *2, *3, *12, *17, *22;
CYP3A5 *2, *3, *3B, *3C, *6, *7, *8, *9;
OPRM1 NM_000914.3:c.118A>G(p.N40D); rs1799971

Note that “*” (read as “star”) denotes the common name of a haplotype (or combination of alleles within a gene on the same chromosome).

Individuals who meet the defined clinical criteria for being prescribed specific drugs for psychotropic medications and pain management.

The test uses custom manufactured TaqMan® drug metabolism and SNP genotyping assays in 384-well format that are run on the QuantStudio™ 6 Flex platform. The complete test consists of two components: SNP genotyping and copy number quantification. The SNP genotyping component consists of 64 TaqMan® SNP Assays for 63 loci, which include single base and short insertion/deletion polymorphisms. The copy number component consists of one TaqMan® Copy Number assay for the CYP2D6 gene.

Pharmacogenetics Expanded Panel (MPG01)

Requisition Forms

• Comprehensive Molecular Test Requisition Form

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